Aug 20, 2019 transdermal fentanyl matrix patches matrifen and durogesic dtrans are bioequivalent. Durogesic dtrans patches are available in packs of 5 patches for all strengths. It is written for patients and gives information about taking or using a medicine. Important things you need to know about durogesic dtrans transdermal patches you have ever had persistent headaches or a head injury. What durogesic dtrans patches contain each durogesic dtrans 50 micrograms hr transdermal patch contains 8. Durogesic dtrans 75 mcghr transdermal patch not available. Fentanyl medicinal forms bnf content published by nice. When a pharmaceutical company changes any document, a new version is published on medicines. The patches work by slowly releasing fentanyl through the skin into the bloodstream over 48 to 72 hours, allowing for longlasting pain management. Durogesic 50 microgramh fentanyl transdermal patches. Evaluation of efficacy and safety of fentanyl transdermal patch durogesica rdtrans in chronic pain article in acta neurochirurgica 1531. Durogesic dtrans 25 mcghr transdermal patch summary of product characteristics smpc by janssencilag ltd. Transdermal fentanyl matrix patches matrifen and durogesic dtrans are.
Use in elderly patients data from intravenous studies with fentanyl suggest that elderly patients may have reduced clearance, a prolonged halflife, and they etrans be more sensitive to the active substance than younger patients. The patient information leaflet pil is the leaflet included in the pack with a medicine. Bioequivalence, in terms of exposure and the maximum and minimum serum concentrations, has been established between the fentanyl transdermal matrix patch 16. Durogesic dtrans 12 mcghr transdermal patch leaflet. Comparison of adhesion and dissolution of fentanyl patches. Transdermal matrix fentanyl patches matrifen or durogesic dtrans 100 microgh were applied for 72 h to 30 healthy male subjects in a randomized, fourperiod two replicated treatment sequences. The rectangularshaped, transparent durogesic dtrans patches are used for consistent pain relief for patients suffering from. In young children, the upper back is the preferred location to minimise the potential of the child removing the patch. Abstral, actiq, duragesic, durogesic uk, fentanyl oralet, fentora, lazanda, matrifen ca, onsolis, ranfentanyl ca, ratiofentanyl ca, sublimaze pharmacologic class. Transdermal fentanyl matrix patches matrifen and durogesic dtrans are bioequivalent. Evaluation of efficacy and safety of fentanyl transdermal patch durogesic d trans in chronic pain. Questions and answers on durogesic and associated names.
Dosage is based on the size of the patch, since, in general, the transdermal absorption rate is constant at a constant skin temperature. Park jh1, kim jh, yun sc, roh sw, rhim sc, kim cj, jeon sr. May 04, 2019 transdermal fentanyl matrix patches matrifen and durogesic dtrans are bioequivalent. Durogesic is available in the eu under various trade names including durogesic dtrans and durogesic matrix. Durogesic dtrans patch is a rectangular shaped, clear, patch with fentanyl 75 g fentanylh printed in blue on one side with a sticky back so that it can be stuck onto the skin.
Patient information for durogesic dtrans 50 mcghr transdermal patch including dosage instructions and possible side effects. Evaluation of efficacy and safety of fentanyl transdermal patch durogesic dtrans in chronic pain. Best practice example of a patient information leaflet. Please note patients are being contacted directly by mail rather than through the use of press advertising. The active surface area of each durogesic dtrans 75 patch is 31.
Durogesic dtrans 12 mcghr transdermal patch summary of. Do not apply more patches, apply the patches more often, or use the patches in a different way than prescribed by your doctor. Durogesic definition of durogesic by medical dictionary. Lower back pain osteoarthritis rheumatoid arthritis neuropathic pain cancer pain working principle of fentanyl patches. Durogesic dtrans patches are rectangular shaped, clear patches with a sticky back with durogesic 12ug fentanylh in orange marked on the back. For each version, we show the dates it was published on medicines. The transdermal patch is a longacting formulation with a delayed onset of effect initially and a prolonged duration of action.
Durogesic dtrans 75microgramshour transdermal patches. Indications, side effects, contraindications and other prescribing information for durogesic dtrans on mims. Fentanyl patches may be habit forming, especially with prolonged use. This study was conducted to determine the analgesia and adverse effects of the fentanyl transdermal patch durogesic dtrans postelective laparotomy. Durogesic dtrans patch introduction the durogesic dtrans is a painrelieving, transdermal patch applied to the skin for severe chronic conditions. Fentanyl patches have been developed using patch design technologies that use the transdermal route. This medicinal product is subject to additional monitoring and it is therefore important to report any suspected adverse events related to this medicinal product. The pharmacokinetic profiles of the two commercially available transdermal fentanyl patches matrifen. In patients with cancer pain, transdermal fentanyl patch could be an efficient and. Fentanyl patches durogesic for chronic pain nps medicinewise. Efficacy of fentanyl transdermal patch in the treatment of chronic. Duragesic fentanyl transdermal system cii pain patch. Durogesic dtrans transdermal patch may also be used for purposes not listed in this medication guide. Durogesic dtrans 25 mcghr transdermal patch summary of.
It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged. Durogesic dtrans 12 transdermal patch durogesic dtrans 25 transdermal patch durogesic dtrans 50 transdermal patch durogesic dtrans 75 transdermal patch durogesic dtrans 100 transdermal patch fentanyl the name of your medicine is durogesic dtrans 12, 25, 50, 75, 100. Butrans, transtec, durogesic dtrans and matrifen transdermal patches can be cut in half. Janssencilag 25ghour transdermal patches, batch number 8fcsc00, may have been incorrectly filled using irish stock of the same batch number, instead of uk stock. Aug, 2019 durogesic dtrans 12 mcghr transdermal patch patient information leaflet pil by janssencilag ltd. Each patch is marked in coloured printing ink as follows. Fentadur and durogesic dtrans article in journal of pharmaceutical investigation 455 may 2015 with 264 reads how we measure reads. Durogesic dtrans 100 mcghr transdermal patch leaflet. Durogesic dtrans 12 mcghr transdermal patch patient. Transdermal opioid patches have been associated with medication errors. Durogesic dtrans 100microgramshour transdermal patches. A strong prescription pain medicine that contains an opioid narcotic that is used to manage pain severe enough to require daily aroundtheclock, longterm treatment with an opioid, in people who are already regularly using opioid pain medicine, when other pain treatments such as nonopioid pain medicines or immediaterelease opioid medicines do not treat your.
Sep 21, 2007 durogesic dtrans patches can be used in opioidtolerant patients aged two to 16 years who are already receiving at least 30mg oral morphine equivalent per day. Transdermal fentanyl matrix patches matrifen r and. Durogesic dtrans patches are available in packs of 5 patches. Durogesic dtrans 75microgramshr transdermal patch fentanyl patient information leaflet 6 further information what is in your medicine the active substance in durogesic dtrans patches is fentanyl. Durogesic dtrans should be applied to nonirritated and nonirradiated skin on a flat surface of the torso or upper arms. Durogesic dtrans 12 microgramshour transdermal patch.
What durogesic dtrans patches looks like and contents of the pack. The agencys committee for medicinal products for human use c hmp concluded that there is a need to harmonise. Evaluation of efficacy and safety of fentanyl transdermal patch ncbi. Durogesic and associated names european medicines agency. Iatrogenic addiction following opioid administration is rare. Fentanyl is a potent opioid used as an analgesic for pain therapy. Aug 04, 2019 transdermal fentanyl matrix patches matrifen and durogesic dtrans are bioequivalent. Transdermal fentanyl matrix patches matrifen and durogesic.
Fentanyl transdermal matrix patch durotep mt patch. Questions and answers on durogesic and associated names fentanyl transdermal patches outcome of a procedure under article 30 of directive 200183ec. Fentanyl transdermal patch durogesic dtrans for post. Read the medication guide and, if available, the instructions for use provided by your pharmacist before you start using. Durogesic dtrans 12mcghr transdermal patch fentanyl patient information leaflet 6 further information what is in your medicine the active substance in durogesic dtrans patches is fentanyl. Evaluation of efficacy and safety of fentanyl transdermal. Sep 12, 2012 the fentanyl transdermal matrix patch is approved in japan for the management of moderate to severe cancerrelated pain in adults. Do not cut durogesic dtrans patches should not be cut a patch that has been divided, cut or damaged in any way should not be used. It contains the active substance fentanyl and is available as a transdermal patch a patch that gradually delivers the medicine through the skin. Transdermal matrix fentanyl patches matrifen or durogesic dtrans 100. The revised durogesic dtrans transdermal patch summary of product characteristics smpc and patient information leaflet can be found electronically on medicines information online, via the website at. Please check with the pharmacist or prescribing doctor. Tolerance, physical dependence and psychological dependence may develop upon repeated administration of opioids. The fentanyl transdermal patch durogesic dtrans is a strong pain medication for moderate to severe chronic pain that can provide longlasting relief for persistent pain.
Opioid analgesic, anesthesia adjunct controlled substance schedule ii pregnancy risk category c action binds to specific opioid. Durogesic dtrans 12 microgramshr transdermal patch 2. Durogesic dtrans is a translucent, rectangular transdermal patch with rounded corners. Durogesic dtrans transdermal patch is used for pain after surgery, moderate to severe chronic pain in opioidtolerant individuals 2 years of age and older and other conditions. Fentanyl is an opioid a pain medicine related to morphine. The aim of this study was to compare the adhesion and dissolution properties of two fentanyl patches, fentadur pfizer inc. Patient information for durogesic dtrans 25 mcghr transdermal patch including dosage instructions and possible side effects. Grey what durogesic dtrans patches look like and contents of the pack durogesic is a clear, rectangular patch with rounded corners, marked with the product name, strength and a border in coloured ink. The durogesic dtrans 75 microgramshr transdermal patch contains 12.
Transdermal fentanyl matrix patches matrifen and durogesic dtrans. Aug 12, 2019 durogesic dtrans is for transdermal use. The second half of the patch cannot be kept for future use. Please click the following product name to access the full smpc durogesic dtrans 12 mcghr transdermal patch durogesic dtrans 25 mcghr transdermal patch durogesic dtrans 50 mcghr transdermal patch durogesic dtrans 75 mcghr transdermal patch.